A study of over 130,000 adults with insomnia found that long-term melatonin use (over a year) was associated with a higher risk of heart failure, hospitalization, and death. The study, presented at the American Heart Association’s Scientific Sessions 2025, raises concerns about the safety of melatonin, a widely used sleep aid. Researchers emphasize the need for further research to assess melatonin’s cardiovascular safety.

A study of 130,828 adults with insomnia found a potential link between melatonin use and heart failure. The study, using data from the TriNetX network, compared 65,414 participants prescribed melatonin for at least a year to a control group. While the study raises safety concerns, it cannot prove a direct cause-and-effect relationship, highlighting the need for further research.

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